Jumonji, a Nuclear Protein That Is Necessary for Normal Heart Development

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Jumonji, a nuclear protein that is necessary for normal heart development.

Jumonji (jmj) was cloned in a gene trap screen to identify and mutagenize genes important for heart development. To investigate the role of jmj in heart development, we generated mice homozygous for the jmj mutation. The jmj homozygous mouse embryos showed heart malformations, including ventricular septal defect, noncompaction of the ventricular wall, double-outlet right ventricle, and dilated ...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 2000

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.86.9.932